The Week 6 college football schedule does not feature any ranked vs. ranked matchups, but several top teams will go on the road for difficult contests. No. 4 Tennessee is a 13.5-point favorite at Arkansas in the Week 6 college football odds, while No. 9 Missouri is a 1.5-point underdog at Texas A&M. Elsewhere, No. 1 Alabama is a 24-point favorite at Vanderbilt, and No. 10 Michigan is a 3-point underdog at Washington.  

No. 25 UNLV hosts Syracuse as a 4.5-point favorite, and No. 6 Oregon is a 24-point favorite against Michigan State in the Week 6 college football spreads on Friday night. 

Before making any college football picks for those games or others in Week 6, be sure to see what the SportsLine Projection Model has to say. 

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen STRONG returns!

Now, it has studied the latest college football odds (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for every Week 6 game, and the results are in. 

One of the college picks the model is high on during Week 6: Iowa (+20.5) stays within the big spread at No. 3 Ohio State in a 3:30 p.m. ET matchup on Saturday, with the Hawkeyes covering in over 60% of simulations.

Another prediction: California (+11.5) plays a one-score game against No. 8 Miami in a 10:30 p.m. ET kickoff on Saturday. The model has the Golden Bears covering well over 60% of the time.  

The model has also made the call on who wins and covers in every other FBS matchup, and it's calling for seven underdogs to win outright!

So which college football teams should you back in Week 6, and which underdogs win outright? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned well over $2,000 in profit on top-rated ATS picks since its inception! ... You've unlocked our best deal! Get your first month of SportsLine for ONLY $1 with the promo code "LEAGUE"! Join here!